The Promise and Peril of Charitable Choice: Religion, Poverty Relief, and Welfare Reform in the South

This study analyzes narratives of welfare reform and faith-based poverty relief articulated by religious leaders in rural Mississippi congregations. These congregations are situated in and around Mississippi\u27s Golden Triangle Region, a locale that includes a diverse group of small and mid-sized towns, as well as remote rural areas. As a state with entrenched social disadvantage, a thriving religious economy, and the nation\u27s first faith-based welfare reform program, Mississippi is an ideal locale to study this important issue. We begin by discussing the charitable choice provision in welfare reform legislation. This legal provision bars discrimination against religious organizations as social service providers. We then briefly outline the poverty relief strategies utilized in a purposive sample of thirty Mississippi religious congregations that vary by denomination, racial composition, and size. Finally, we analyze pastors\u27 appraisals of charitable choice, paying special attention to the various rationales they enlist to justify their evaluations of this policy initiative. We conclude by discussing our study\u27s implications for charitable choice implementation in the rural South

Mooney Award Committee Report

The 2001 James Mooney Award Committee Teviewed ten books submitted by six university presses. As we made our final evaluations we soon reached a consensus that two of the ten books were superior in meeting the criteria for the Mooney Award. Creating Freedom: Material Culture and African American Identity at Oakley Plantation, Louisiana, 1840-1950 / by Laurie Wilkie (2000, Louisiana State University Press). Reviewed by Hester A. Davis, Mooney Award Committee, Arkansas Archeological Survey The Estuary\u27s Gift: An Atlantic Coast Cultural Biography / by David Griffith (1999, Pennsylvania State University Press). Reviewed by Helen Regis, Mooney Award Committee, Louisiana State Universit

Myoblasts and macrophages share molecular components that contribute to cell–cell fusion

Cell–cell fusion is critical to the normal development of certain tissues, yet the nature and degree of conservation of the underlying molecular components remains largely unknown. Here we show that the two guanine-nucleotide exchange factors Brag2 and Dock180 have evolutionarily conserved functions in the fusion of mammalian myoblasts. Their effects on muscle cell formation are distinct and are a result of the activation of the GTPases ARF6 and Rac, respectively. Inhibition of ARF6 activity results in a lack of physical association between paxillin and β1-integrin, and disruption of paxillin transport to sites of focal adhesion. We show that fusion machinery is conserved among distinct cell types because Dock180 deficiency prevented fusion of macrophages and the formation of multinucleated giant cells. Our results are the first to demonstrate a role for a single protein in the fusion of two different cell types, and provide novel mechanistic insight into the function of GEFs in the morphological maturation of multinucleated cells

IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors

Muscle damage has been shown to enhance the contribution of bone marrow–derived cells (BMDCs) to regenerating skeletal muscle. One responsible cell type involved in this process is a hematopoietic stem cell derivative, the myelomonocytic precursor (MMC). However, the molecular components responsible for this injury-related response remain largely unknown. In this paper, we show that delivery of insulin-like growth factor I (IGF-I) to adult skeletal muscle by three different methods—plasmid electroporation, injection of genetically engineered myoblasts, and recombinant protein injection—increases the integration of BMDCs up to fourfold. To investigate the underlying mechanism, we developed an in vitro fusion assay in which co-cultures of MMCs and myotubes were exposed to IGF-I. The number of fusion events was substantially augmented by IGF-I, independent of its effect on cell survival. These results provide novel evidence that a single factor, IGF-I, is sufficient to enhance the fusion of bone marrow derivatives with adult skeletal muscle

Probing BRD inhibition substituent effects in bulky analogues of (+)-JQ1

A series of bulky organometallic and organic analogues of the bromodomain (BRD) inhibitor (+)-JQ1 have been prepared. The most potent, N-[(adamantan-1-yl)methyl]-2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamide, 2e, showed excellent potency with an KD=ca. 130 nm vs. BRD4(1) and a ca. 2-fold selectivity over BRD4(2) (KD=ca. 260 nm). Its binding to the first bromodomain of BRD4 was determined by a protein cocrystal structure

An interferon-free antiviral regimen for HCV after liver transplantation.

Background Hepatitis C virus (HCV) infection is the leading indication for liver transplantation worldwide, and interferon-containing regimens are associated with low response rates owing to treatment-limiting toxic effects in immunosuppressed liver-transplant recipients. We evaluated the interferon-free regimen of the NS5A inhibitor ombitasvir coformulated with the ritonavir-boosted protease inhibitor ABT-450 (ABT-450/r), the nonnucleoside NS5B polymerase inhibitor dasabuvir, and ribavirin in liver-transplant recipients with recurrent HCV genotype 1 infection. Methods We enrolled 34 liver-transplant recipients with no fibrosis or mild fibrosis, who received ombitasvir-ABT-450/r (at a once-daily dose of 25 mg of ombitasvir, 150 mg of ABT-450, and 100 mg of ritonavir), dasabuvir (250 mg twice daily), and ribavirin for 24 weeks. Selection of the initial ribavirin dose and subsequent dose modifications for anemia were at the investigator's discretion. The primary efficacy end point was a sustained virologic response 12 weeks after the end of treatment. Results Of the 34 study participants, 33 had a sustained virologic response at post-treatment weeks 12 and 24, for a rate of 97% (95% confidence interval, 85 to 100). The most common adverse events were fatigue, headache, and cough. Five patients (15%) required erythropoietin; no patient required blood transfusion. One patient discontinued the study drugs owing to adverse events after week 18 but had a sustained virologic response. Blood levels of calcineurin inhibitors were monitored, and dosages were modified to maintain therapeutic levels; no episode of graft rejection was observed during the study. Conclusions Treatment with the multitargeted regimen of ombitasvir-ABT-450/r and dasabuvir with ribavirin was associated with a low rate of serious adverse events and a high rate of sustained virologic response among liver-transplant recipients with recurrent HCV genotype 1 infection, a historically difficult-to-treat populatio

Doing Oral History as Public Anthropology

Doing Oral History engages students as co-researchers in a community-engaged oral history project begun in 2011. Supported by a research partnership between a faculty member, a university oral history center, and a non-profit archive, the course engages learners in the exploration of a festival and its communities. Through oral histories with long-time festival workers, artists, staff, volunteers, and neighbors, we contribute to expanding the history of a festival and the social movements that have shaped it. We also consider the ways in which diverse festival workers come to feel a part of a community centering African American working-class folk, cultures, and performance traditions. Students learn from narrators connected to the festival, recording their life histories, and learning about neighborhood and city history, cultural traditions, and social movements. These oral histories engage the complex racialized, classed, and gendered hierarchies which the festival reflects, the central place of folklore and cultural heritage in the public culture of the region, and the challenges of making a living in a precarious tourism economy. In this article, I reflect on how the class contributes to doing and teaching public anthropology in the South

Ships on the Wall: Retracing African Trade Routes from Marseille, France

With this essay on decolonizing ways of knowing, I seek to understand the phantom histories of my father’s French family. Filling in silences in written family accounts with scholarship on Marseille’s maritime commerce, African history, African Diaspora studies, and my own archival research, I seek to reconnect European, African, and Caribbean threads of my family story. Travelling from New Orleans to Marseille, Zanzibar, Ouidah, Porto-Novo, Martinique and Guadeloupe, this research at the intersections of personal and collective heritage links critical genealogies to colonial processes that structured the Atlantic world. Through an exploration of family documents, literature, and art, I travel the trade routes of la Maison Régis